• The song won a 2000 Grammy Award for Best Rock Song. The song is about Anthony Kiedis and is battle with drugs. 'Sarcastic Mister know it all' is a reference to Dave Navarro, who is regarded by him as the King of Sarcasm.
• Anthony Kiedis, Flea, Chad Smith, & John Frusciante share writing credits on the song. Rick Rubin produced the track for the album 'Californication'. The music video was directed by fashion photographer/director Stephane Sednaoui, who also directed the videos for 'Give It Away' & 'Breaking The Girl'
• The single was released in May of 1999 and peaked at #9 on the Billboard Hot 100 chart. It also peaked at #15 on the UK Singles chart.
• 'Scar Tissue' topped the Billboard Modern Rock Tracks chart from June 26th, 1999 to October 9th, 1999. It also topped the Billboard Hot Mainstream Rock Track chart from July 17th, 1999 to September 18th, 1999.